Alexis Edwards

Biography:

Alexis received her BS in chemistry from the University of Mary Hardin-Baylor (Belton, TX) in 2018 and is expected to graduate with a Ph.D. in 2023. In her free time, she enjoys watching movies with her husband, cross stitching, and playing video games.

 

Current Area:

Alexis's research can broken into two distinct projects: (1) using ion mobility (IM) paired with native mass spectrometry (MS)  to investigate structural differences of proteins and protein complexes in positive- and negative-ion mode and (2) using native IM-MS to investigate how proteins bind to single-stranded DNA.

 

Presentations:

Poster Presentation, “Determining the gas-phase stability of chloramphenicol acetyltransferase and the effects of ligand binding” 71st ASMS Conference on Mass Spectrometry and Allied Topics, June 2023

Poster Presentation, “Towards understanding the effect of isoelectric point on the gas-phase stability of proteins in native MS” 71st ASMS Conference on Mass Spectrometry and Allied Topics, June 2023

Poster Presentation, “IMS-MS Investigation of Protein Structure and Stability when Sprayed from Solutions with Different pH Values” 71st ASMS Conference on Mass Spectrometry and Allied Topics, June 2023 *Poster composed by undergraduate researcher in coordination with Alexis

Poster Presentation, “Hypothesized gas-phase trimeric gp2.5 protein complex confirmed to be trimeric chloramphenicol acetyltransferase​,” 70th ASMS Conference on Mass Spectrometry and Allied Topics, June 2022. 

Poster Presentation, “Investigating the contribution of isoelectric point on protein gas-phase unfolding when sprayed from positive- or negative-ion mode​,” 69th ASMS Conference on Mass Spectrometry and Allied Topics, November 2021. 

Poster Presentation, “​Propagating error associated with TWIMS calibrations increases the accuracy of calculated CCS values,” 68th ASMS Conference 'Reboot' Online Only, June 2020. 

Poster Presentation, “​Comparison of native mass spectrometry in positive and negative-ion mode for proteins with varying isoelectric points,” 2nd Advancing Mass Spectrometry for Biophysics and Structural Biology Meeting , July 2019. 

Publications:

  1. Edwards, A. N.; Blue, A. J., Conforti, J. M., Cordes, M. S.; Trakselis, M. A., Gallagher, E. S. Gas-phase stability and thermodynamics of ligand-bound, binary complexes of chloramphenicol acetyltransferase reveal negative cooperativity. Anal. Bioanal. Chem. 2023, 415 (25), 6201-6212. DOI: 10.1007/s00216-023-04891-5

  2. Edwards, A. N.; Tran, H. M.; Gallagher, E. S. Propagating Error through Traveling-Wave Ion Mobility Calibration. J. Am. Soc. Mass Spectrom. 2021, 32 (11), 2621-2630. DOI: 10.1021/jasms.1c00144

Awards:

Nomination for 'Outstanding Graduate Student Instructor Award", Baylor University (2022)

Graduate Research Productivity Award, Baylor University (2021)

Magna cum laude, University of Mary-Hardin Baylor



Contact Information:

Alexis_Edwards2@baylor.edu