Jacob Hatvany
Biography:
Jacob joined the Gallagher Lab in 2019. He graduated from Harding University in 2017 with a B.S. in chemistry. Jacob enjoys spending time with his family and exploring the local and state parks around Waco. He is a coffee connoisseur (read “snob”) and can often be found in one of Waco’s many coffee houses (Pinewood is his favorite). Jacob is a big fan of reading and not just of scientific articles! He enjoys reading Sci-Fi/Fantasy as well as community-focused fiction. In addition to his work in chemistry, Jacob has spent his time at Baylor involved with the Graduate School as well as Baylor’s Academy for Teaching and Learning to study pedagogical best practices, reflect on the intersection of Faith and Higher Education, and learn about the common perceptions of Faith and Science.
Current Area:
RAPID REACTIONS AND SWEET ANALYSIS
Jacob’s research includes investigating the effect of spray solvent pH on In-Electrospray Ionization (ESI) Hydrogen/Deuterium Exchange (HDX)of carbohydrates as well as peptides. Since every functional group that contains a labile Hydrogen undergoes a base and/or acid-catalyzed mechanism of exchange, solution pH is expected to have a large effect on the overall amount of exchange observed. For more info, check out doi:10.1021/jasms.3c00341. In addition to this work, Jacob investigates the creation of theta emitters (borosilicate capillaries composed of two distinct channels separated by an interior septum) pulled to a fine tip with openings ranging from submicron to tens of microns. These theta emitters can be used to establish rapid mixing experiments (like in-ESI HDX) when different solutions are sprayed from each channel. Based on the size of the channel openings as well as the distance from the mass spectrometer, different reaction lifetimes can be achieved. Finally, Jacob also looks at the utility of an interior coating being applied to nano-ESI (nESI) capillaries for the analysis of carbohydrates as well as carbohydrate-conjugates.
Presentations:
Poster Presentation, “Characterization and comparison of θ-capillary and single-channel capillary tip generation for use in nESI” Jacob B. Hatvany, Emma-Le Olsen, Elyssia S. Gallagher 71st ASMS Conference on Mass Spectrometry and Allied Topics, June 2023
Poster Presentation, “Effect of PEG-modification to capillaries for analysis of carb and carb-containing molecules using nESI” Emma-Le Olsen, Jacob B. Hatvany, Chih-Chieh Hseih, Craig A. Aspinwall, Elyssia S. Gallagher 71st ASMS Conference on Mass Spectrometry and Allied Topics, June 2023 *Poster composed by undergraduate researcher in coordination with Jacob
Oral Presentation, “Studying Glycans Utilizing In-Electrospray Ionization Hydrogen/Deuterium Exchange Mass Spectrometry” Jacob B. Hatvany, Elyssia S. Gallagher Harding University, Searcy, AR, October 2022.
Poster Presentation, “Observing the effect of pH on H/D exchange during in-ESI HDX of carbohydrate-metal adducts” Jacob B. Hatvany, Ana Quintero, Elyssia S. Gallagher 2022 Graduate Research Showcase, Baylor University, Waco, TX, October 2022.
Poster Presentation, “Observing Effects of Charge Carrier on In-electrospray H/D Exchange of Component Moieties in Glycopeptides,” Jacob B. Hatvany, Elyssia S. Gallagher 70th ASMS Conference on Mass Spectrometry and Allied Topics, June 2022.
Poster Presentation, “Observing the effect of pH on H/D exchange during in-ESI HDX of carbohydrate-metal adducts” Jacob B. Hatvany, Ana Quintero, Elyssia S. Gallagher 69th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, PA, November, 2021
Poster Presentation, “In-ESI HDX of Carbohydrate-metal Adducts in Solvated ESI Droplets: Effects of Metal Ions and Counter Ions” O. Tara Liyanage, Emvia I. Calixte, Ana V. Quintero, Jacob B. Hatvany, Elyssia S. Gallagher 68th ASMS Conference on Mass Spectrometry and Allied Topics, 2020
Oral Presentation, “Human Breath as a Medical Diagnostic for Space Missions” Jacob B. Hatvany, Edmond V. Wilson, Jr. Arkansas Space Grant Consortium April, 2017, Morrilton, AR
Poster Presentation, “Methodology for Measuring Pentane in Human Breath.” Jacob B. Hatvany, Edmond V. Wilson, Jr. Arkansas INBRE November, 2015, Fayetteville, AR
Awards:
Publications:
Hatvany, J. B.; Olsen, E. P.; Gallagher, E. S. Characterizing Theta-Emitter Generation for Use in Microdroplet Reactions. J. Am. Soc. Mass Spectrom. 2024, XX (XX), XXX-XXX. DOI: 10.1021/jasms.4c00262Olsen, E. P.; Gallagher, E. S. Characterizing Theta-Emitter Generation for Use in Microdroplet Reactions. J. Am. Soc. Mass Spectrom. 2024, XX (XX), XXX-XXX. DOI: 10.1021/jasms.4c00262
Hatvany, J. B.; Liyanage, O. T.; Gallagher, E. S. Effect of pH on In-Electrospray Hydrogen/Deuterium Exchange of Carbohydrates and Peptides. J. Am. Soc. Mass Spectrom. 2024, 35 (3), 441-448. DOI: 10.1021/jasms.3c00341
Gass, D. T.; Quintero, A.V.; Hatvany, J.B.; Gallagher, E. S. Metal adduction in mass spectrometric analyses of carbohydrates and glycoconjugates. Mass Spectrom. Rev. 2024, 43 (1), 615-659. DOI: 10.1002/mas.21801
Hatvany, J. B.; Gallagher, E. S. Hydrogen/deuterium exchange for the analysis of carbohydrates. Carbohydr. Res. 2023, 530, 108859. DOI: 10.1016/j.carres.2023.108859
Liyanage, O. T.; Quintero, A. V.; Hatvany, J. B.; Gallagher, E. S. Distinguishing Carbohydrate Isomers with Rapid Hydrogen/Deuterium Exchange-Mass Spectrometry. J. Am. Soc. Mass. Spectrom. 2020, 32 (1), 152-156. DOI: 10.1021/jasms.0c00314
Garcia, A. P.; Hatvany, J. B.; Murphy, M. A.; Atchley, D. H.; Gurley, B. J.; Kamdem, L. K., Effect of Aromatase Inhibition (Exemestane) on Urine Concentration of Osteoprotegerin in Healthy Postmenopausal Women. J. Clin. Pharmacol. 2020, 60 (2), 209-217. DOI: 10.1002/jcph.1519
2024 - 2nd Place in Baylor 3 Minute Thesis
2023 Graduate Research Productivity Award
2022 Outstanding Graduate Research Award in STEM
2022 Ron Hites Award from ASMS
2022 Conyers Graduate Scholar, 2022 Baylor Libraries Data Scholar, 2023 RAMM Scholar
2022 Teaching Capstone in Higher Education (TeaCHE) and Designing for Online Teaching Success (DOTS)
2021, 2022, 2023 Baylor University Travel Award
2019 Nomination for “Outstanding Graduate Student Instructor”
Certificate of Excellence in Mentoring Undergraduate Research